Regional Neuroprotective Effects of the NMDA Receptor Antagonist MK-801 (Dizocilpine) in Hypoglycemic Brain Damage
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چکیده
منابع مشابه
The NMDA antagonist dizocilpine (MK-801) reverses haloperidol-induced movement initiation deficits.
The present study shows that systemic dopamine receptor blockade impaired movement initiation of rats, trained in a simple reaction time task for rapid initiation of locomotion in response to a combined optic/acoustic cue. Reaction time, movement time and the accelerative force were recorded for each initiation of locomotion. Results indicate a dose-related increase of reaction time following s...
متن کاملModeling the effects of the NMDA receptor antagonist MK-801 on timing in rats.
The NMDA receptor antagonist MK-801 produces different effects on timing tasks. In particular, MK-801 produces an underestimation of duration when animals are tested with the differential reinforcement of low rate of responding (DRL) schedule and an overestimation of duration when animals are tested with the peak-interval (PI) procedure. The goal of this study was to develop a model-based expla...
متن کاملInhibition of morphine withdrawal by the NMDA receptor antagonist MK-801 in rat is age-dependent.
This study investigated the effects of the NMDA receptor antagonist MK-801 on the development of morphine dependence in 7-, 14-, and 21-day-old rat pups. For 6.5 days, starting at 1, 8, or 15 days of age, rats were pretreated with MK-801 (0.03 or 0.1 mg/kg, bid) or saline; 15 min later, morphine sulfate (10 mg/kg) or saline was injected to induce opiate dependence. On the afternoon of the seven...
متن کاملEffects of the Nmda Receptor Antagonist Mk-801 on the Timing and Temporal Processing of Short-intervals in Rats
Kevin C. H. Pang, Advisor J. Devin McAuley, Co-Chair The present series of studies examined effects of MK-801, an NMDA antagonist, on short-interval timing in rats. The first study used two experiments to examine timing performance using the peak-interval (PI) and PI-gap procedures during chronic exposure of MK801. The first of these experiments investigated the effects of three MK-801 doses (0...
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Interactions between excitatory amino acids and opioids were examined by studying the ability of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 to affect morphine catalepsy and lethality. MK-801 (0.3 mg/kg) reduced the ED50 for morphine-induced catalepsy from approximately 30 mg/kg to less than 10 mg/kg, and reduced the LD50 for morphine from approximately 100 mg/kg t...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 1990
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.1990.44